IDH2 and acute myeloid leukemia: TET2 loss-of-function mutations and IDH1/2 neomorphic mutations are mutually exclusive in the AML cohort, and they show similar DNA methylation alteration.673 IDH mutants produce oncometabolite D-2-hydorxyglutarate (D2-HG) that competitively inhibits α-KG-dependent TET enzymes.