On the other hand, DCs are implicated in the induction of central and peripheral immune tolerance, and they achieve tolerogenic/immunosuppressive functions under the stimulation of various factors, such as IL-10, TGFβ, and vitamin D3.414 This is often co-opted by tumors to shift the phenotypes of infiltrating DCs from immunogenic to tolerogenic, which dampens antitumor immunity and promotes tumor progression.415 The maturation and functional plasticity of DCs in TME involves methylation remodeling across DNA/RNA/protein and related writers, erasers, and readers. This evidence concerns the gene IL10 and neoplasm.