Dendritic cells (DCs) are heterogeneous and comprise four main subtypes: conventional DC 1 (cDC1), conventional DC 2 (cDC2), plasmacytoid DC (pDC), and monocyte-derived DC (moDC).413 DCs not only are professional APCs that present antigens on MHC II molecules to prime CD4+ T cells but also are the main APCs that crosspresent tumor-associated antigens on MHC I molecules to activate CD8+ T cells, which is essential for antitumor immunity. The gene discussed is CD8A; the disease is neoplasm.