METTL3 and osteoarthritis: For example, METTL3 expression and m6A level are elevated in fibroblast-like synoviocytes (FLS) of patients with osteoarthritis, which inhibits autophagy and promotes senescence of the cells by targeting ATG7 mRNAs (an enzyme crucial for the formation of autophagosomes) for degradation.612 Inhibition of METTL3 ameliorates the FLS senescence and osteoarthritis progression in mouse models.