METTL3 and cancer: Increasing evidence indicated that elevation in mRNA m6A level is involved in the EMT and cancer metastasis.294,295 Upregulation of METTL3 or downregulation of FTO promotes methylation of SNAIL or Wnt pathway transcripts, respectively, which enhances the translation or stability of target mRNAs that mediate the EMT process294,295 (Fig. 4b).