METTL3-catalyzed m6A modification of COL10A1 transcripts in CAFs enhances the mRNA stability and protein level, which protects lung squamous cell carcinoma from apoptosis-induced oxidative stress and promotes cancer cell proliferation.496 Zfp217-FTO-YTHDF2 axis is involved in the adipogenic differentiation of mouse fibroblast cells,497 suggesting a potential role of m6A remodeling in regulating CAF fate. This evidence concerns the gene METTL3 and cancer.