The tumor microenvironment (TME) is typically composed of immune cells (e.g., T lymphocytes, natural killer cells, macrophages, neutrophils, dendritic cells), stromal cells (e.g., fibroblasts and mesenchymal stromal cells), blood and lymphatic vessels, extracellular matrix (e.g., collagens, fibronectins, and elastin) and other secreted molecules by tumor and non-tumor cells (e.g., cytokines, growth factors, and chemokines) (Fig. 5). The gene discussed is ELN; the disease is neoplasm.