Similarly, histone H3 deacetylation and H3K4 demethylation are involved in the silence of intercellular adhesion molecule-1 (ICAM-1) in tumor ECs, leading to reduced leukocyte-endothelial cell adhesion and consequently less inflammatory infiltration.462 In contrast, the expression of cell adhesion molecules in the ECs of distant tissues is crucial for circulating tumor cell adhesion, extravasation, and metastasis. The gene discussed is ICAM1; the disease is neoplasm.