Of note, Lrat-Cre-mediated deletion of Pdgfrb inhibited HSC activation, liver fibrosis, and tumorigenesis in Mdr2−/− mice in the study of Filliol et al. [9], which further suggests that down-regulation of PDGFR-β transcription by Ccne1 inhibition is mechanistically related to reduced fibrogenesis and hepatocarcinogenesis in our own experimental setting. Here, CCNE1 is linked to Hepatic fibrosis.