CCNE1 and hepatocellular carcinoma: Regarding the pro-inflammatory response upon DEN/CCl4 challenge, we found a significant up-regulation of interleukin 6 (Il6) mRNA expression in fibrosis- and HCC-bearing Ccne1f/f mice, which was reduced to almost background levels of untreated controls after HSC-specific deletion of Ccne1 in Ccne1ΔHSC mice.