Among the 1068 drugs, three drugs (Lbrutinib, Promethazine hydrochloride, and Vemurafenib) showed comparable or higher necroptosis-rescuing effects than Nec-1 (Fig. 1B), which were further validated in murine dermal fibroblast MDF and human colon cancer cells HT29. This evidence concerns the gene PCSK1 and colonic neoplasm.