These are more often of the IDHwt phenotype than purely INGs, which are more likely to have IDH1 mutations, associated with favorable outcome, and smaller tumor volume (p < 0.007).26The IDHwt phenotype, implicated with worse prognosis, is more common in paralimbic INGs leading to their association with shorter OS and PFS than purely insular tumors, as in the study by Tang and colleagues.26However, this review concludes that paralimbic gliomasshould notbe considered as a single entity. The gene discussed is IDH1; the disease is neoplasm.