IDH1 and neoplasm: While traditionally regarded as an indicator of tumor progression,58epileptic seizures have been linked to IDH-mutant gliomas with better prognosis.59, 60, 61, 62Mutant IDH1 increases d-2-hydroxyglutarate (D2HG), a glutamate mimetic contributing to increased neuronal excitation and seizures.62Moreover, according to Wang and colleagues,23the larger putaminal-invading tumors and glioblastomas were less likely to present with seizures than purely INGs.