BUB1 and neoplasm: However, while some markers have been found to harbour predictive or prognostic value in retrospective studies (eg, BUB1 and PINK1 mRNA,29, 30 hypermethylation of PAX5,31, 32G0S2,33 and RRM134), it will be important to test their value prospectively in patients with localised disease who are allocated to adjuvant mitotane or surveillance alone after complete tumour resection.