reported that CGA regulates the gut microbiota, increases the expression of intestinal ZO‐1 and occludin proteins, reduces the levels of inflammatory factors (IL‐1β and IL‐6), and maintains intestinal homeostasis.[33] We elucidated the efficacy of rectal administration of CGA in rats with PI‐IBS, but the specific mechanism remains to be explored. The gene discussed is TJP1; the disease is irritable bowel syndrome.