OCLN and irritable bowel syndrome: and the expression of the intestinal tight junction (TJ) proteins occludin and zonula occludens‐1 (ZO‐1), protects the intestinal barrier, and reduces the inflammatory response.[12] Moreover, the bioavailability of CGA is largely dependent on its metabolism by the gut microbiota, and these microbial‐derived metabolites account for 57.4% of the total intake of CGA.[13] Therefore, we hypothesized that CGA might alleviate the symptoms of PI‐IBS by interacting with the gut microbiota or exerting intestinal and neuroprotective effects.