The new findings showing NS1 similarities with the HDL in their lipid composition and receptor usage, and the capability of NS1 to bind to the HDL particles themselves or its protein moiety Apo-A1, are exciting and suggest new ways NS1 may contribute to dengue pathogenesis, including increased virus replication, cytokine storm, and thrombocytopenia (Fig 1). The gene discussed is APOA1; the disease is dengue disease.