Conversely, blocking mitochondrial OXPHOS with oligomycin potentiated melanoma cell response to vemu without affecting CD36+ cell abundance (Supplemental Figure 10B), further indicating that the peroxisome/UGCG-mediated lipid metabolism and the mitochondria-mediated OXPHOS independently promote drug tolerance in different melanoma cell subpopulations. Here, UGCG is linked to melanoma.