Knocking down CaV3.1 or CaV3.2 did not impede the ability of NNC to potentiate vemu-induced apoptosis or the NNC-mediated decrease in the CD36+ melanoma cell population (Supplemental Figure 8, H and I), suggesting that the effects that we observe with NNC are largely attributable to its inhibitory effect on PEX3-PEX19 binding rather than on TTCCs. This evidence concerns the gene PEX3 and melanoma.