Here, we combined a well-established induction of CAC (De Robertis et al., 2011; McIntyre et al., 2015; Parang et al., 2016) with a BM transplantation (BMT) approach to experimental CH driven by heterozygous Dnmt3a loss (Guryanova et al., 2016a, 2016b). Here, DNMT3A is linked to cyclic hematopoiesis.