DNMT3A and cyclic hematopoiesis: CH is most frequent in the elderly (10–40%) and is commonly driven by somatic mutations in leukemia-associated genes such as DNMT3A (Bick et al., 2020; Busque et al., 1996, 2012; Coffee et al., 2017; Genovese et al., 2014; Guermouche et al., 2020; Jaiswal et al., 2014; McKerrell et al., 2015; van Zeventer et al., 2021; Xie et al., 2014; Young et al., 2016; Zink et al., 2017).