Inflammatory conditions such as osteoarthritis (Han et al. 2016; Chang et al. 2019) and renal inflammation (Lavoz et al. 2015; Lavoz et al. 2018) and damage are promoted by GREM1 overexpression, potentially via VEGFR2 signaling (Lavoz et al. 2015). The gene discussed is GREM1; the disease is osteoarthritis.