HDAC2 and cancer: In addition, we observed a significant downregulation of 29 transcription factors associated with immune cell homeostasis and cancer control across all AML samples, including ZBTB7A, NR3C1, ELF2, KLF13, KLF2, XBP1, RXRA, FOSL2, and HDAC2 (Fig. 3f and 3g).