In addition to transcription factors, in AML samples, we identified the upregulation of genes that were reported to accelerate leukaemogenesis, including S100A8, S100A9, and RPS26 [26, 27], and the downregulation of genes related to cancer control and defence, such as XIST, GIMAP7, NKG7, and GNLY (Supplementary Fig. 7). This evidence concerns the gene GNLY and acute myeloid leukemia.