This study not only incorporates traditional clinical features from the IPI, such as age, LDH, and Ann Arbor Stage but also includes additional essential clinical variables, such as CD4/CD8, β2-microglobulin, LYM, CRP, and B symptoms, to construct a comprehensive and advanced prognostic nomogram model for DLBCL. This evidence concerns the gene CD8A and diffuse large B-cell lymphoma.