In their study, the exposure of BPF before and after adjustment was 0.4 versus 0.3 ng/mL, respectively, which was much less than the BPA exposure of 1.5 versus 1.1 ng/mL [52], and studies have shown that BPF can interfere with the IRS-1/PI3K/AKT signal transduction pathway and subsequently affect the insulin-dependent glucose metabolism pathway of adipocytes (3T3-L1 adipocytes), resulting in obesity [53]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.