It has been proposed that ongoing autoimmunity in the EAE mouse model is likely to represent the defective function of Tregs and lose FOXP3 expression under inflammatory conditions and can be induced to express proinflammatory cytokines, such as IL-17 and IFNγ (IFNγ+ FOXP3+ IL-17A+) (52, –, 54). Here, IFNG is linked to Autoimmunity.