Dendritic Cells (DC) from hypertensive mice CD80high and CD86high (common B7 ligands), which points to DC maturation and activation.47 In our experiment, MLNs from SLE mice showed higher CD80 and CD86 mRNA levels as compared to CTR mice, and only RS treatment restored their levels like CTR group (Figure S9B). Here, CD80 is linked to systemic lupus erythematosus.