TLR7 and systemic lupus erythematosus: The patients with SLE reported a lower fiber intake than healthy humans.23,24 Moreover, an inverse association between dietary fiber intake and the risk of active SLE has been described.25 In agreement with this association, Zegarra-Ruiz et al. 15, using TLR7-dependent mouse models of SLE, found that a diet high in RS leads to greater SCFAs production to restrict growth of Lactobacillus reuteri, reducing the translocation from the gut to distal organs, and rescues lupus-prone mice from autoimmunity.