Interestingly, the SCFAs receptor GPR43 transcript was increased GF-RS (Figure S12E), whereas mRNA levels of HDAC3 were reduced in GF-ITF as compared to GF-SLE (Figure S12F), showing a role of SCFAs in the colonic effects of the microbiota from fiber-treated SLE mice inoculated into GF, despite GF mice-fed standard diet. Here, FFAR2 is linked to systemic lupus erythematosus.