In consequence, the percentage of Th17 cells (CD4+/IL-17a+) increased ≈ 2.8-fold in SLE mice in MLNs (Figure 4a), being Treg (Treg, CD4+/CD25+) and Th1 (CD4+/IFN-γ+) unchanged. The gene discussed is CD4; the disease is systemic lupus erythematosus.