2020, 2021) previously reported that compared with Nold seniors, patients with MCI and mild dementia due to AD showed poor (1) callosal, thalamic, and anterior–posterior WM bundles; (2) cortical GM volume in association with in-vivo neuroimaging maps of abnormal deposition of tau and amyloid; (3) correlation of resting-state functional MRI-BOLD signal in the DMN and DAN; and (4) functional coupling of rsEEG alpha rhythms among anterior and posterior cortical areas. The gene discussed is MAPT; the disease is dementia.