Parkinson’s disease (PD) is a progressive neurodegenerative disorder that encompasses several pathogenic processes that converge on the accumulation of misfolded α-synuclein (α-Syn) in Lewy bodies and neurites, and degeneration of dopaminergic neurons in the substantia nigra, resulting in an array of motor, cognitive, neuropsychiatric and autonomic deficits1–3. Here, SNCA is linked to Parkinson disease.