High USP6 expression in patients with Ewing sarcoma was associated with significantly improved overall survival, as well as all molecular hallmarks of a “hot” tumor microenvironment (TME; ref. 20), defined as an IFN response gene signature, production of the chemokine CXCL10, and infiltration of CD8+ T lymphocytes (21). This evidence concerns the gene USP6 and Ewing sarcoma.