USP6 also triggered surface stabilization of the type I and type II IFN receptors, IFNAR1 and IFNGR1, rendering Ewing sarcoma cells hyperresponsive to ectopic IFNs with resultant synergistic induction of IFN response genes, including CXCL10 (20). This evidence concerns the gene CXCL10 and Ewing sarcoma.