We posit that in vivo, this feedforward loop creates a highly immunostimulatory, chemokine-rich TME, which leads to further recruitment and activation of not only NK cells, but also CD8+ T lymphocytes, macrophages, and DCs, as is seen in Ewing sarcoma patient samples with high USP6 expression (20). The gene discussed is CD8A; the disease is Ewing sarcoma.