As shown by the immunofluorescent (IF) and IHC (immunohistochemistry) staining (Figure 1A and Figure S1E), fibrosis‐associated markers like Desmin and Masson significantly decreased on day 3, while SM22 (smooth muscle 22) and αSMA (alpha smooth muscle actin) declined on days 5 and 7, respectively, after CCl4 withdrawal, confirming the resolution of liver fibrosis. This evidence concerns the gene DES and Hepatic fibrosis.