However, clinical presentation with intense pruritus and urticarial prodrome, laboratory findings with eosinophilia and elevated IgE, histopathology findings consist of sub-epidermal bullae with a dermal infiltrate of eosinophils and neutrophils, as well as recent expanding evidence from in vitro and in vivo experiments all implicate type II inflammation as an important driver of BP pathogenesis (28). This evidence concerns the gene IGHE and Increased total eosinophil count.