Moreover, hypermethylation in ESR1, CDX2, GATA5, and APC has been reported in CRC patients (Dawson et al., 2014; Sahnane et al., 2015; Liang et al., 2017; Liu et al., 2017; Zhu et al., 2021). This evidence concerns the gene GATA5 and colorectal carcinoma.