MTSS1 and colorectal cancer: MTSS1 is a metastasis suppressor gene that is frequently hypermethylated in leukemia and prostate, gastric, and bladder cancers, excluding colorectal cancer, where there are no reports (Utikal et al., 2006; Yamashita et al., 2006; Xie et al., 2011; Chen et al., 2020; Grandits et al., 2021).