F. nucleatum has been associated with CIMP+ and the promoter methylation of MLH1, CDKN2A, MTSS1, RBM38, PKD1, PTPRT, and EYA4, which are mutated and dysregulated in CRC according to the COSMIC database (Tate et al., 2019). The gene discussed is EYA4; the disease is colorectal carcinoma.