PDHA1 and neoplasm: For instance, the deacetylase SIRT3 acts as a tumor suppressor in several cancer cells and contributes in deacetylating PDHA1, a subunit of the pyruvate dehydrogenase complex (PDC), thereby inducing its activity and causing an anti-Warburg effect via the HIF1alpha/PDK1/PDHA1 pathway (71).