intervention changed the methylation levels at 16,064 CpG sites;These CpGs sites were related to cancer, cell cycle-related, MAPK, Rap1, and Ras signaling pathways;regardless of hypocaloric intervention, a group of 878 CpGs (related to 649 genes) remained significantly altered in obese women when compared with normal-weight women;Pathway enrichment analysis identified genes related to the cadherin and Wnt pathway, angiogenesis signaling, and p53 pathways by glucose deprivation. The gene discussed is CDH17; the disease is cancer.