MAD1L1 and obesity due to melanocortin 4 receptor deficiency: By intersecting the results of all studies analysing genome-wide methylation changes based on lifestyle interventions we identified 47 genes which were affected in two independent studies and even one gene which was reported by three studies – MAD1L1. Although the role of this cell cycle and tumor suppression relevant gene for obesity was not yet investigated, one recent study showed differently blood methylation of MAD1L1 in infants of obese mothers (109).