KLK3 and cancer: In at least four randomised-controlled trials, the positive detection rates of csPCa between non-image-based and MRI-informed biopsy approaches were not significantly different.5–8 In a very recent paper, Eklund et al.29 found that in a screening context using PSA ⩾ 3 ng/ mL and MRI-based biopsies found similar rates of csPCa compared to conventional investigations (21% vs 18%), and the main benefit was reduced rates of insignificant cancers detected.