Despite accumulating achievements in the non-invasive microbial diagnosis of CRC, few studies have investigated cancer prognosis, and most studies are limited to tests relying on Fn. Due to the negative correlation between the abundance and survival of Fn, it may serve as a promising prognostic indicator for CRC (Mima et al., 2015; Yamaoka et al., 2018). Here, FN1 is linked to colorectal carcinoma.