TARDBP and amyotrophic lateral sclerosis: For example, TDP-43, a protein whose aggregation is a hallmark of ALS and other neurodegenerative diseases, can be expressed in Drosophila larval motor neurons or in accessible adult structures (eyes, legs, or wings) to evaluate the pathways leading to motor neuron dysfunction and loss (Li et al., 2010; Estes et al., 2011; Sreedharan et al., 2015).