When we subcutaneously inserted a small piece of the 90-Pa fibrin gel containing 10 B16 cells into wild-type C57BL/6 or NSG mice, we found that compared to SGCTRL B16 cells, MAFG knockout strikingly decreased the tumor formation of B16 cells in NSG mice (10/10 versus 2/10) and in wild-type mice (4/10 versus 0/10) (Fig. 7A). The gene discussed is MAFG; the disease is neoplasm.