To determine the role of YAP in tumor cell dedifferentiation, we constructed nuclear location signal (NLS)- and nuclear export signal (NES)-tagged YAP-expressing cells and found that NLS-YAP abrogated the above tumor cell dedifferentiation, while exporting YAP from the nucleus (NES-YAP) promoted dedifferentiation, as evidenced by colony formation and SOX2 expression (Fig. 3D and E and Fig. S3H). Here, SOX2 is linked to neoplasm.