Therefore, in this study, we adopt this method and provide evidence that partially differentiated breast and melanoma cancer cells use integrin β8 to sense a low mechanical force, which inactivates Yes-associated protein (YAP) and relieves its suppression of v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G (MAFG), leading to transactivating stemness genes and tumor cell dedifferentiation. This evidence concerns the gene YAP1 and neoplasm.