The implication of dysregulated BDNF in depression is also supported by both human post-mortem (Duman and Li, 2012) and rodent (McEwen, 2007; Castrén and Rantamäki, 2010) studies, showing that human depression and rodent models of depression are associated with decreased expression of several neurotrophic factors, including BDNF. This evidence concerns the gene BDNF and depressive disorder.