Differential levels in the hypothalamus of four proteins related to nerves, including prolargin (PRELP), microtubule-associated protein 1 B (MAP1B), transmembrane protein 41 B (TMEM41B), NMDA receptor synaptonuclear-signaling, and neuronal migration factor (NSMF), are involved in the MMWA treatment of insomnia (Xu et al., 2020). The gene discussed is PRELP; the disease is insomnia.