The involvement of miR‐374 family members has been mainly described in tumorigenesis, including carcinoma of the digestive system.(58) Few targets of miR‐374a‐3p have been validated, including WNT3 in colon adenocarcinoma;(59)RUNX2, a regulator of osteogenesis differentiation;(60) and AXIN2, whose decreased expression might promote osteosarcoma.(61). Here, AXIN2 is linked to osteosarcoma.