Interestingly, our data suggest a differential impact of preptin deficiency on liver triglyceride storage between males and females, so elevated preptin in diabetic states could be more beneficial to females than males regarding triglyceride accumulation in the liver, which is a hallmark of nonalcoholic fatty liver disease.(47) The gene expression of Igf2 (exon 2–3) in liver of preptin KO mice was previously assessed and found not to be different between KO and WT mice. Here, IGF2 is linked to metabolic dysfunction-associated steatotic liver disease.