MAPT and early-onset autosomal dominant Alzheimer disease: Even though the mechanism by which physical activity improves brain health are yet to be more determined, studies highlighted a number of mechanisms in which exercise may modulate brain health, this involves an influence on Alzheimer's disease pathology (decrease deposition of Aβ and hyperphosphorylated tau), growth factors release (neutrophils), regulation of hormonal levels along with an improvement in brain volume and functional health.