ADORA2A and amyotrophic lateral sclerosis: Mori et al. aimed to investigate the potential of the A2A receptor (A2AR) as a target for ALS therapy and reviewed the potential pathways of chronic neurodegeneration via the adenosinergic system, the potential of UA as a biomarker, and the acute symptomatic pharmacology of A2A receptor antagonism (including phrenic motor facilitation).