In gene ontology analysis using IPA, the diseases and disorders most relevant to the predicted Neat1-interacting genes that were upregulated (106 mRNAs) and downregulated (76 mRNAs) by Neat1 in neuropathic pain were inflammatory response and neurological disease (Figures 5D, E), respectively, similar to the analysis of genes whose expressions were changed by Neat1 knockdown regardless of Neat1 interactions (553 genes; Figure 3E). Here, NEAT1 is linked to nervous system disorder.