Similar to other studies we observed an anti-inflammatory systemic effect of IL-6 regulation by dexamethasone in COVID-19 (6, 12) but dexamethasone has also been shown to fail in the inhibition of IL-6, TNF and CXCL10 expression in the lung microenvironment (75), pointing out a possible inefficiency of regulating local hyperinflammatory response in the lungs. The gene discussed is TNF; the disease is COVID-19.