STMN2 and frontotemporal dementia: However, as STMN2 RNA levels are also reduced in the frontal cortex of FTD patients (Prudencio et al., 2020), it is important to assess the contribution of STMN2 deficiency to FTD-associated phenotypes, in particular given the recent development of therapeutic strategies to rescue STMN2 splicing and restore STMN2 expression and function.