STMN2 splicing is regulated by TDP-43, such that in conditions of TDP-43 deficiency, a cryptic exon is included within the RNA, leading to the production of a non-functional truncated STMN2 variant and the concomitant loss of full-length STMN2 in ALS and FTD cases (Klim et al., 2019; Melamed et al., 2019; Prudencio et al., 2020). This evidence concerns the gene TARDBP and frontotemporal dementia.