PLG and laryngotracheoesophageal cleft: Ligneous conjunctivitis (LC) is the main complication of Type I Plasminogen Deficiency (T1PD; OMIM# 217,090), a rare autosomal recessive systemic disease caused by mutations in the gene PLG encoding for plasminogen (PLG; OMIM# 173350) located on chromosome 6q26, resulting in reductions in both the levels of immunoreactive PLG and its functional activity [1].