Aoki et al. [93] and Durante et al. [94] identified a novel regulatory T-cell-like immunosuppressive subset of lymphocyte activation gene 3 (LAG3)+ T cells that contribute to the immune-escape phenotype in classic Hodgkin lymphoma (CHL) and uveal melanoma (UM), respectively, that may be a target for immune checkpoint blockade (ICB). This evidence concerns the gene LAG3 and Hodgkins lymphoma.