We validated a robust negative correlation between the expression levels of RSPO2 and its DNA methylation status at its promoter region in all CRC samples analysed (Fig. 4D), suggesting that the impairment in cell proliferation may be the consequence of the epigenetic reactivation and subsequent restoration of the gene expression levels of RSPO2 in CRC cancer cells. The gene discussed is RSPO2; the disease is colorectal carcinoma.