EPHA2 and neoplasm: Another study found that treatment with S1MP-EphA2- siRNA-DOPC in mice with SKOV3ip1 tumor cells significantly reduced tumor weight by 54.2% and 65.3% compared with non-silencing control siRNA-DOPC and S1MP- non-silencing control-siRNA-DOPC, respectively (p < 0.05; ANOVA F = 4.92) [48].