Table 3 shows that in multivariate analysis (Forward: LR), Hyperuricaemia (OR: 5.24, 95% CI: 1.40—19.65, P = 0.014) is independent positively correlated with DKD in T1DM patients, while the other independent related factors for DKD in patients with T1DM are the Hb level (OR: 0.94, 95% CI: 0.91- 0.96, P < 0.001), duration of DM (OR: 1.14, 95% CI: 1.07—1.22, P < 0.001), HbA1c (OR: 1.42, 95% CI: 1.19—1.68, P < 0.001), DBP (OR: 1.07, 95% CI: 1.04—1.11, P < 0.001) and TG (OR: 1.67, 95% CI: 1.06—2.62, P = 0.027). The gene discussed is GSTM1; the disease is diabetes mellitus.