Similar to our case, other inherited developmental disorder complicated with ICGN had been occasionally reported, including cohorts of RH [27], WT1-nephropathy [28], Alport Syndrome [29], a case of COL4A5 nephropathy [30], etc. Although the mechanism has not been elucidated, it indicated that those structural renal anomalies may increase the incidence of ICGN. Here, COL4A5 is linked to Alport syndrome.