TGFB1 and cancer: Previous studies pointed to an up-regulatory effect of M2 TAMs and TAFs on the expression of IL-10 and TGF-β [66, 67], IL-6 and MMPs [12, 68], and the endothelial mesenchymal transition (EMT)-related genes, e.g., vimentin [69] in cancer cells which subsequently dampened the efficacy of ICD.