AKT1 and ischemia: Hypothermia protected neurons from neuronal ischemia/reperfusion-induced pyroptosis through m6A-mediated activation of phosphatase and tensin homologous protein (PTEN) and the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) / protein kinase B (Akt) / glycogen synthase kinase-3β (GSK-3β) signaling pathway [287].