WDR4 mutation impaired m7G46 methylation of specific tRNA species and caused a distinct form of microcephalic primordial dwarfism [369] and was likely the cause for Galloway-Mowat syndrome in an Indian family, who displayed phenotypes such as developmental delay, growth deficiency, intellectual disability, and microcephaly [370]. Here, WDR4 is linked to isolated growth hormone deficiency type IA.