TARDBP and amyotrophic lateral sclerosis: Recovering ADAR2 level in the ADAR2-depleted mechanistic sporadic ALS mouse model by intravenously injecting adeno-associated virus serotype 9 (AAV9)-ADAR2 rescued mice from motor neuron death by normalizing TDP-43 expression, suggesting a possibility of using AAV9-mediated ADAR2 gene delivery as a gene therapy for ALS [307].