A defect in the editing of the mRNA transcript led to an unedited Q/R site in the GluA2 subunit of glutamate AMPAR in the spinal motor neurons of patients with ALS, interfering with the correct functioning of the glutamate receptors and may thereby cause neuronal death in ALS patients [16, 304]. The gene discussed is GRIA2; the disease is amyotrophic lateral sclerosis.