GRIA1 and Alzheimer disease: A recent study revealed a m6A methylation decrease in brains of aged mice and AD patients compared to young mice and cognitively intact human subjects, respectively, in transcripts related to synaptic function, including AMPA-selective glutamate receptor 1 (Glua1) and calcium/calmodulin-dependent protein kinase 2 (CAMKII), resulting in decreased synthesis of synaptic proteins, such as GLUA1 and CAMKII [283].