METTL3 and acute myeloid leukemia: Compound 5a − d also exhibited potent METTL3 inhibition (IC50 < 10 nM) and selectivity over METTL1/16 and displayed similar cellular functions in MOLM-13 AML cells, such as decreasing cellular mRNA m6A level and impairing proliferation (Fig. 6a) [385].