In endometrial cancer, m6A methylation reduction by either METTL14 mutations or METTL3 downregulation led to the stabilization of mRNAs encoding members of the AKT pathway, decreased PHLPP2 expression and increased mTORC2 expression, leading to AKT pathway activation and cell proliferation [176]. The gene discussed is AKT1; the disease is endometrial cancer.