NSUN2 and breast carcinoma: Similar analysis by Huang and colleagues on 11 m5C RNA methylation regulators (NSUN2-7, DNMT1, DNMT3A/B, ALUREF and TET2) in breast cancer databases demonstrated that NSUN2 overexpression closely correlated to cell cycle signaling pathways, RNA polymerase, spliceosome, and RNA degradation, whereas NSUN6 depletion correlated to metabolism, extracellular matrix receptor interaction, and cell adhesion [184].