A more recent study showed that FTO promoted melanoma tumorigenesis as well as tumor resistance to interferon gamma (IFNγ) and anti-PD-1 treatment by demethylating m6A from crucial pro-tumorigenic mRNAs, including programmed cell death 1 (PDCD1), SRY-Box Transcription Factor 10 (SOX10) and CXC-chemokine receptor 4 (CXCR4), leading to increased mRNA stability (Fig. 3a) [180]. The gene discussed is FTO; the disease is neoplasm.