Bioinformatic analysis of N1-methyladenosine (m1A) regulators (TRMT6/61A, RRP8, ALKBH1/3, YTHDF1-3, YTHDC1) in LUSC revealed that most of the m1A regulators were significantly upregulated in cancer tissues compared to normal samples [200]. The gene discussed is YTHDF1; the disease is cancer.