Yan et al. demonstrated that inhibiting FTO demethylase activity with Rhein sensitized resistant cells to tyrosine kinase inhibitors (TKIs) and downregulated B-cell lymphoma-2 (Bcl-2) and MER proto-oncogene, tyrosine kinase (MERTK), suggesting that combinatorial treatment with Rhein and TKIs may be an effective approach to treat leukemia [406]. This evidence concerns the gene MERTK and leukemia.