For example, NSUN2 promotes tumor metastasis and cisplatin resistance by methylating NMR (also known as LINC01672) ncRNA, which in turn recruits BPTF and promotes the expression of matrix metalloproteinase 3 (MMP3) and MMP10 in esophageal squamous cell carcinoma (Fig. 3b) [199]. This evidence concerns the gene NSUN2 and esophageal squamous cell carcinoma.