NAT10 promoted ER stress-mediated metastasis and apoptosis resistance to Lenvatinib in HCC cells by increasing the ac4C acetylation level of HSP90AA1 mRNA, maintaining the stability of HSP90AA1, thereby upregulating HSP90AA1 expression (Fig. 3f) [277]. Here, HSP90AA1 is linked to hepatocellular carcinoma.