CYBB and cancer: In human urothelial carcinoma cells, ALKBH3 contributed to cancer survival, invasion and angiogenesis by mediating the level of NADPH oxidase-2 (NOX-2)-generated reactive oxygen species (ROS), as well as the expression levels of tumor necrosis factor-like weak inducer of apoptosis (Tweak), Vascular endothelial growth factor (VEGF) and fibroblast growth factor-inducible 14 (Fn14) (Fig. 3c) [208].