Regulation of m1A modification significantly correlated with the pathogenesis of human Abdominal Aortic Aneurysm (AAA), where the m1A reader, YTHDF3, modulated macrophage polarization and regulated the expression of key AAA-related target genes, including signal transducer and activator of transcription 3 (STAT3), CD44, ITGB1 and mTOR [214]. This evidence concerns the gene STAT3 and triple-A syndrome.