Targeting NAT10 with Remodelin induced apoptosis by enhancing ER stress in AML cells through the increased expression of G Protein-Coupled Receptor 78 (GRP78) and the cleavage of caspase 12, although at a relatively high dose (125 μM), further supporting the potential of Romedelin in clinical applications [483]. Here, NAT10 is linked to acute myeloid leukemia.