STING1 and neoplasm: On the other hand, pairwise analysis between CINlow and Sting1-depleted CINhigh tumour cells did not reveal significant enrichment in the ER stress (normalized enrichment score (NES) = −0.85, false discovery rate (FDR) = 0.83) or type I IFN (NES = 0.56, FDR = 0.95) pathways, suggesting that Sting1 depletion abolishes CIN-dependent effects in tumour cells.