CASP8 and Yersinia infectious disease: Inflammasome activation and cell death are reduced in macrophages lacking RIPK3 and CASP8 or RIPK3 and FADD compared with cells deficient in RIPK3 in response to LPS + ATP stimulation and C. rodentium or Yersinia infection, indicating that FADD and CASP8 regulate inflammasome activation and pyroptosis during NLRP3 inflammasome stimuli61–63.