Several ‘APM-associated genes’, including CYP11B2 itself, as well as the ACTH receptor gene MC2R, the neuronal genes NETO2 and BEX1, and TSPAN12, had 2–8-fold lower expression in ZG samples adjacent to an APA than in ZG samples adjacent to a phaeochromocytoma, for example20,107,115,132–139. The gene discussed is MC2R; the disease is pheochromocytoma.