CYP11B2 and Hypertension resistant to conventional therapy: After many years during which candidate drugs demonstrated insufficient selectivity to avoid inhibiting 11β-hydroxylase – which is responsible for cortisol synthesis and exhibits close homology to aldosterone synthase – a 12-week phase II trial of baxdrostat, which exhibits 100:1 selectivity for aldosterone synthase, demonstrated a comparable blood pressure reduction in patients with resistant hypertension to that achieved previously in similar patients using spironolactone120,175.