KCNJ5 and Hypertension: A set of somatic KCNJ5 mutations, which also occasionally appear in the germline – for example, Thr158Ala, Gly151Arg and Glu145Gln – cause a florid Mendelian syndrome with macroscopic adrenal hyperplasia, early-onset hypertension and hypokalaemia18,54,55.