In contrast, Reilly and coworkers have shown that TRPV1 may play a more dominant role in capsaicinoid toxicity in non-cancerous lung cells, and some role in human lung adenocarcinoma (A549) cells, which were more sensitive to the cytotoxic effect of capsaicin than human hepatocarcinoma (HepG2) cells, which expressed less TRPV1 receptor55,63. This evidence concerns the gene TRPV1 and lung adenocarcinoma.