AD and control separation was driven by two functional groups of proteins (indicated by arrows in the Fig. 5A): (1) energy metabolism and cell proliferation proteins (i.e. key glycolytic proteins ALDOA, PKM and cell proliferation regulating PEBP1, all highly correlated in CSF (r2 > 0.8); (2) vascular panel proteins, involved in blood coagulation and inflammation (VTN, F2, KNG1, AMBP). The gene discussed is PKM; the disease is Alzheimer disease.