These include neuroinflammation, a core feature of AD6, where targeted metabolomic profiling of lipid mediators in matched plasma and cerebrospinal fluid (CSF) samples revealed evidence for a role of soluble epoxide hydrolase (sEH) and ethanolamides (a class of endocannabinoids) in AD-associated pathologies7. The gene discussed is EPHX2; the disease is Alzheimer disease.