To this end, we included apolipoprotein E (ApoE), a critical apolipoprotein involved in PUFA and oxylipin trafficking with clear AD-associations29 and TNFα Receptor Associated Factor 4 (TRAF4), an inflammatory cascade regulator upregulated in brains of AD cases30 with expression levels reportedly associated with EPHX2 in cerebrum31. Here, APOE is linked to Alzheimer disease.