SPP1 and Alzheimer disease: In AD cases, the greatest number of associations were formed with the specific BA ratios representing the relative activity of the classic and alternative BAs synthesis pathways, calculated using conjugated BAs: (TCA + GCA + TDCA + GDCA)/(GUDCA + TUDCA + GLCA + TLCA + TCDCA + GCDCA), that showed negative associations with ENO2 (Spearman’s ρ = -0.32) and positive associations with proteins involved in blood coagulation and ECM interaction (CP, KNG1, AMBP, PON1, LUM, SPP1, VNT and AHSG with Spearman’s ρ = 0.29, 0.41, 0.5, 0.34, 0.35, 0.36, 0.29, 0.38 and 0.47 respectively).