To explore the correlation between LGSN expression levels and clinical GC progression, the gene set enrichment analysis (GSEA) analysis using the TCGA dataset was utilized, which further revealed that genes significantly up-regulated along with high-LGSN expression were related to “gastric advanced progression” and “regulation of stem cell population maintenance” in GC cells (Fig. 1F). The gene discussed is LGSN; the disease is gastric cancer.