In particular, we determined the IC50 values of 5-FU (Fig. 6B; Supplementary Fig. S14B), cisplatin (Supplementary Fig. S14C), L-OHP (Fig. 6B), and Metformin (Supplementary Fig. S14D) (clinically approved drugs may induce pyroptosis in cancers [24]) in LGSN-high and LGSN-low gastric cancer patients in TCGA database. This evidence concerns the gene LGSN and cancer.