LGSN and neoplasm: The amount of severely apoptotic and necrotic cell death GC cells significantly increased, consistent with the significant reduction in tumor proliferation and pyroptosis markers, in both the shLGSN group and combination treatment group, suggesting LGSN-knockdown-mediated vimentin depletion effectively triggered pyroptotic cell death signaling and promoted chemotherapeutic effects on the gastric tumor in vivo (Fig. 7E–G).