Meanwhile, vimentin is also one of the key factors contributing to the actin cytoskeleton reorganization in invasive/metastatic GC cells [19] and is significantly associated with poor overall survival, first progression, and progression-free survival in GC patients (Supplementary Fig. S8F), indicating vimentin could be the most likely functional LGSN-binding candidate involved in cell stemness maintenance and the most suitable for further investigation. Here, LGSN is linked to gastric cancer.